PALLADIUM-COPPER CATALYSTS FOR THE HOMOGENEOUS SELECTIVE OXIDATION OF THIOL GROUPS

摘要

A palladium-copper catalyst of homogeneous selective oxidation of thiols is proposed, combining a functional binuclear thiolate-bridged coordination compound of palladium (II) and a modifying thiolate complex of copper (I), having the general formula
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ[Pd 2 II (µ-SR) 2 (NH 3 ) 4 ] · {Cu I k (SR) m }€ƒ€ƒ€ƒ€ƒ€ƒ(I),
where
SR is the residue of a thiolate ligand, chosen from the group including a residue of glutathione and acetylcysteine,
k = 2 to 14,
m ‰¥ 3k. Also proposed are a catalytic combination, a pharmacological combination, a pharmaceutical composition, and a method of therapeutic action on a patient's organism based on the indicated catalyst.