| 发明名称 |
VARIABLE DOMAINS OF LIGHT AND HEAVY CHAIN OF MURINE MONOCLONAL ANTIBODY AGAINST TUMOUR NECROSIS FACTOR ALPHA (TNF-?) OF HUMAN BEING (VERSIONS); ANTIGEN-BINDING FRAGMENT (Fab) AGAINST TNF-? OF HUMAN BEING, WHICH CONTAINS ABOVE SAID DOMAINS (VERSIONS) |
| 摘要 |
FIELD: biotechnologies.SUBSTANCE: invention proposes variable domains of heavy (VH) and light (VL) chains of murine antibody against tumour necrosis factor alpha (TNF-?) of a human being, as well as antigen-binding fragment Fab, which are selectively bound to TNF-? of the human being and neutralise it.EFFECT: invention can be further used in development of medicines for therapy of TNF-?-mediated diseases and for diagnostics of such diseases.3 cl, 5 tbl, 7 ex |
| 申请公布号 |
RU2499000(C1) |
申请公布日期 |
2013.11.20 |
| 申请号 |
RU20120113360 |
申请日期 |
2012.04.06 |
| 申请人 |
OTKRYTOE AKTSIONERNOE OBSHCHESTVO "VSEROSSIJSKIJ NAUCHNYJ TSENTR MOLEKULJARNOJ DIAGNOSTIKI I LECHENIJA" (OAO "VNTSMDL") |
发明人 |
SOLOPOVA OL'GA NIKOLAEVNA;POZDNJAKOVA LJUBOV' PETROVNA;SVESHNIKOV PETR GEORGIEVICH;BENEVOLENSKIJ SERGEJ VLADIMIROVICH;JAGUDIN TIMUR ANVEROVICH;ZATSEPIN SERGEJ SERGEEVICH;MOROZKINA ELENA VLADIMIROVNA;KLJACHKO ELENA VITAL'EVNA |
| 分类号 |
C07K16/24;C12P21/08 |
主分类号 |
C07K16/24 |
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