NOVEL 1,2,3,4-TETRAHYDROQUINOXALINE DERIVATIVE CONTAINING PHENYL GROUP AS SUBSTITUTE, HAVING SULPHONIC ACID ESTER STRUCTURE OR SULPHONIC ACID AMIDE STRUCTURE, AND HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY

摘要

FIELD: chemistry.SUBSTANCE: invention relates to compounds of general formula (1) or salts thereof, where in formula (1)Ris a lower C-Calkyl group, a lower C-Ccycloalkyl group, a phenyl group, a heterocyclic group, which relates to a residue formed by removing a hydrogen atom from a saturated or unsaturated monocyclic heterocyclic ring containing one, two or three heteroatoms in the ring, selected from a nitrogen atom, an oxygen atom and a sulphur atom, or a phenyl(C-Calkyl) group; in cases when Ris a lower C-Calkyl group, that lower C-Calkyl group can have, as substitute(s), one, two or three groups selected from a halogen atom, a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated monocyclic heterocyclic ring containing one or two heteroatoms in the ring, selected from a nitrogen atom and an oxygen atom, a carboxyl group, a lower C-Calkoxycarbonyl group, a lower C-Calkylamino group, a lower C-Calkylamino group, substituted with a lower C-Calkylamino group, a lower C-Calkylamino group, substituted with a phenyl group; in cases when Ris a phenyl group, a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated or unsaturated monocyclic heterocyclic ring containing one, two or three heteroatoms in the ring, selected from a nitrogen atom, an oxygen atom or a sulphur atom, or a phenyl(C-Calkyl) group, that phenyl, heterocyclic or phenyl(C-Calkyl) group can contain, as substitute(s), one, two or three groups selected from a halogen atom, a lower C-Calkyl group, a hydroxyl group or a lower C-Calkoxy group; Ris a hydrogen atom or a lower C-Calkyl group; Ris a hydrogen atom or a lower C-Calkyl group; Rand Rcan be identical or different and are a hydrogen atom or a lower C-Calkyl group; Ris a hydrogen atom or a lower C-Calkyl group; Ris a phenyl group or a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated monocyclic heterocyclic ring containing one heteroatom in the ring, selected from an oxygen atom and a sulphur atom; in cases where Ris a phenyl group or a heterocyclic group which relates to a residue formed by removing a hydrogen atom from a saturated monocyclic heterocyclic ring containing one heteroatom in the ring, selected from an oxygen atom and a sulphur atom, that phenyl or heterocyclic group can contain, as substitute(s), one or two groups selected from a halogen atom, a lower C-Calkyl group, a hydroxyl group, a lower C-Calkoxy group and a nitro group; W is an oxygen atom or NR; Ris a hydrogen atom or a lower C-Calkyl group; X is an oxygen atom or a sulphur atom; Y is a lower C-Calkylene group; Z is an oxygen atom, a sulphur atom, NRor OCO; Ris a hydrogen atom or a lower C-Calkyl group. The invention also relates to a pharmaceutical composition based on said compounds, having GR binding activity.EFFECT: obtaining novel compounds and a pharmaceutical composition based on said compounds, which can be used in medicine as glucocorticoid receptor modulators.10 cl, 1 tbl, 3 ex