| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine and concerns a combined pharmaceutical composition having antibacterial activity. As an active substance, the composition contains a clindamycin salt or ester, a base which is a combination of a hydrophobic ingredient, a hydrophilic ingredient and an emulsifier, and a gelling polymer. A method of preparing the declared composition involves the fact that a solution of the clindamycin salt or ester in a part of the hydrophilic ingredient is added with the gelling polymer, then the emulsion prepared of a residual part of the hydrophilic ingredient, the hydrophobic ingredient and the emulsifier, and the prepared mixture is agitated until smooth.EFFECT: new pharmaceutical formulation is characterised by a high level of antibacterial activity, stability both at storage temperature (25°C), and at temperature of use (37°C), good packaging extrusion.15 cl, 1 dwg, 2 tbl, 4 ex |
