P2X4 RECEPTOR ANTAGONIST

摘要

A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X 4 receptor antagonist:
wherein each of R 21 and R 22 is hydrogen, a C 1-8 alkyl group or the like;
R 23 is hydrogen, a C 1-8 alkyl group or the like;
each of R 24 and R 25 is hydrogen, a C 1-8 alkyl group or the like;
R 26 is hydrogen, a C 1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and
p is 0 or 1.