发明名称 |
METHOD FOR DELIVERING AGENTS INTO CELLS USING BACTERIAL TOXINS |
摘要 |
The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of a eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof. |
申请公布号 |
EP2663337(A2) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20120734614 |
申请日期 |
2012.01.10 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
COLLIER, ROBERT, J.;PENTELUTE, BRAD, L. |
分类号 |
A61K47/48;A61K9/08;A61K9/10;A61K38/08;A61K38/16;A61P31/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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