| 摘要 |
FIELD: biotechnologies.SUBSTANCE: invention proposes compounds of labyrinthpeptins A1, A2, or A3 of formula (I), where {A}, {B}, {C}, R-R, m and n have the values specified in the formula of the invention. Compounds are obtained at fermentation of Actinomadura namibiensis DSM 6313 strain under acceptable conditions in cultural environment till one or more compounds of formula (I) are formed. The invention proposes the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A2, and the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A1, as well as preprolabyrinthpeptins A1 and A2, and prolabyrinthpeptins A1 and A2. Labyrinthpeptins of formula (I) are used for therapy of infections caused by gram-positive bacteria, virus infections and/or neuropathic pain caused by inflammation.EFFECT: improving therapy efficiency.24 cl, 4 tbl, 20 ex |
