发明名称 |
ANTI-IGA1 ANTIBODY |
摘要 |
An object of the present invention is to provide a monoclonal antibody which is effective for diagnosing IgA nephropathy and specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound. According to the present invention, it is possible to provide a monoclonal antibody or an antibody fragment thereof that specifically recognizes and binds to a hinge region of a polypeptide encoded by a heavy chain gene of immunoglobulin A1 that comprises a serine/threonine-linked sugar chain to which galactose is not bound, to provide a diagnostic agent using the antibody or the antibody fragment thereof, and to provide a therapeutic agent comprising the antibody or the antibody fragment thereof as an active ingredient. |
申请公布号 |
EP2520648(A4) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20100841044 |
申请日期 |
2010.12.28 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
KANEKO, ETSUJI;SASAKI, YUKA;MORI, KATSUHIRO;KANDA, YUTAKA;SATOH, MITSUO |
分类号 |
C12N15/09;A61K39/395;A61P13/12;A61P37/02;C07K16/42;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/02;C12P21/08;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|