| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to oral antituberculous agents. The given agent is presented in the form of an enteric-coated granule and contains: sodium para-aminosalicylate - 500 to 900 mg; isoniaside 19 to 26 mg; hydrogenated vegetable oil - 1.1-1.5 mg; crospovidone - 22-31 mg; sodium disulphite - 4-12 mg; methylcellulose - 11-19 mg with a granule density varying within 0.9 to 1.05 g/ml, a enteric coating thickness making 0.2-0.3 mm, a particle size of isoniaside falling within the range that is 2-3 higher than that of sodium para-aminosalicylate, while a particle size of crospovidone is 2-3 times higher than those of sodium para-aminosalicylate and sodium disulphite. All particles of the active ingredients are uniformly distributed throughout the granule.EFFECT: reducing the toxic effect of para-aminosalicylate on the human body.14 ex, 1 tbl |
