Hydrophobic polysaccharides with diester- or carbonate ester-containing linkages having enhanced degradation

摘要

Hydrophobic alpha(1->4)glucopyranose polymers with enhanced degradation properties are described. Between the alpha(1->4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.