发明名称 |
Chiral diene ligands, a fabrication method thereof and applications thereof |
摘要 |
The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene ligand to take part in asymmetric transformations, particularly an asymmetric addition reaction involving a metal catalyst in a basic environment. Most of the products of the reactions implemented by the chiral diene ligands of the present invention have superior optical activity. The method of the present invention comprises a first oxidation step, a saponification step, a second oxidation step, a deprotonation step, and a cross-coupling step. The chiral diene ligand of the present invention is very suitable to be used in the fabrication or synthesis of various chemicals and medical products.
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申请公布号 |
US8586810(B2) |
申请公布日期 |
2013.11.19 |
申请号 |
US201213608222 |
申请日期 |
2012.09.10 |
申请人 |
WU HSYUEH-LIANG;CHEN CHUN-CHIH;LIU CHIA-CHEN;WEI WEI-TING;FANG JO-HSUAN;NATIONAL TAIWAN NORMAL UNIVERSITY |
发明人 |
WU HSYUEH-LIANG;CHEN CHUN-CHIH;LIU CHIA-CHEN;WEI WEI-TING;FANG JO-HSUAN |
分类号 |
C07C1/00;C07C13/465;C07C17/00;C07C19/08;C07C205/00 |
主分类号 |
C07C1/00 |
代理机构 |
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地址 |
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