发明名称 |
ANTIBODY PURIFICATION |
摘要 |
The present invention relates to a method of separating antibodies from contaminants in a solution, which method comprises contacting the solution with a chromatography resin comprised of a support to which multi-modal ligands have been immobilised, wherein a multi-modal ligand comprises at least one cation-exchanging group and at least one aromatic or heteroaromatic ring system. In one embodiment, the ring-forming atoms of the aromatic or hereoaromatic entity are selected among C, S or O, and the cation exchanging group is a weak cation exchanger. The present method may be used as a single step procedure or as a polishing step following a capture on a Protein A column. |
申请公布号 |
CA2552823(C) |
申请公布日期 |
2013.11.19 |
申请号 |
CA20052552823 |
申请日期 |
2005.02.24 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
JOHANSSON, BO-LENNART;JOHANSSON, HANS J.;LJUNGLOEF, ANDERS;MALOISEL, JEAN-LUC;THEVENIN, NICOLAS |
分类号 |
C07K1/16;B01J39/08;C07K16/00;G01N |
主分类号 |
C07K1/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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