| 摘要 |
A peptide having an ED50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular alpha1 loop 2 or beta2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of gamma-secretase activity, an increased release of beta-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED50 value is measured by bioassay.
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