TRIAZOLE-SUBSTITUTED ARYLAMIDE DERIVATIVE AND ITS USE AS P2X3 AND/OR P2X2/3 PURINERGIC RECEPTOR ANTAGONIST

摘要

PROBLEM TO BE SOLVED: To provide compounds useful for treatment of diseases associated with P2X purinergic receptors, and P2X3 and/or OR P2X2/3 antagonists usable for treatment of genitourinary, pain, inflammatory, gastrointestinal and respiratory diseases, conditions and disorders.SOLUTION: There are provided compounds of formula (I) or a pharmaceutically acceptable salt thereof (in the formula, Ris optionally substituted triazolyl, and Ris optionally substituted phenyl, pyridinyl, pyrimidinyl, pyridazinyl or the like, R, R, R, R, Rand Rare substituents such as Calkyl, or R, Rand Rtogether with the atom to which they are attached may form a six-membered heteroaryl containing one or two nitrogen atoms, and which is optionally substituted with halo, amino or Calkyl).