发明名称 |
PROCESS FOR PREPARATION OF ALBENDAZOLE |
摘要 |
The present invention discloses a novel, cost-effective process for preparation of a benzimidazole carbamates compound. Specifically, it relates to the process for the preparation of anti-parasite bulk drug albendazole. The process comprises a) thiocyanating 2-nitroaniline of formula VI with ammonium thiocyanated in presence of a halogen to obtain 2-nitro-4-thiocyanoaniline of formula V; b)propylating 2-nitro-4-thiocyanoaniline of formula V with propylbromide in presence of n-propanol and a base in absence of a phase transfer catalyst to obtain 4-propylthio-2-nitroaniline of formula III; C) reducing the nitro group of 4-propylthio-2-nitroaniline prepared in step b) by reacting an aqueous alkali metal sulphide or an alkaline metal sulphide to obtain 4-propylthio-o-phenylenediamine of formula II; and d)condensing 4-propylthio-o-phenylenediamine of formula II with alkali or alkaline earth metal salt of methylcyano carbamate in presence of an acid to form Albendazole of formula I.
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申请公布号 |
US2013303782(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
US201113989497 |
申请日期 |
2011.11.23 |
申请人 |
RANE RAMKRISHNA APPAJI;NAITHANI SUSHIL;NATIKAR RAJENDRA DEVENDRA;VERMA SUDHAKAR;ARULMOLI THANGAVEL;SEQUENT SCIENTIFIC LIMITED |
发明人 |
RANE RAMKRISHNA APPAJI;NAITHANI SUSHIL;NATIKAR RAJENDRA DEVENDRA;VERMA SUDHAKAR;ARULMOLI THANGAVEL |
分类号 |
C07D235/32 |
主分类号 |
C07D235/32 |
代理机构 |
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