APOE IMMUNOTHERAPY

摘要

The disclosure provides antibodies that preferentially bind to an ApoE(1-272) fragment relative to ApoE(1-299). Further disclosed are humanized monoclonal antibody comprising three light chain Kabat CDRs and three heavy chain Kabat CDRs with framwork modifications. These antibodies serve to reduce the toxicity of this fragment and find use in treatment and prophylaxis of a variety of neurological diseases.