发明名称 |
METHODS AND COMPOSITIONS FOR INFUSION OF TRANSIENTLY ENGRAFTING, SELECTED POPULATIONS OF ALLOGENEIC LYMPHOCYTES TO TREAT CANCER |
摘要 |
The invention provides methods and compositions for administration of allogeneic lymphocytes as an an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells. Depletion of CD8+ T cells from the donor lymphocyte infusion reduces the risk of sustained engraftment and graft-versus-host disease. Removal of regulatory T cells from the infused population may augment the ability of non-regulatory T cells to provide help for endogenous effectors of anti-tumor immunity. Allogeneic T cell therapy is typically given in the context of allogeneic stem cell transplantation, in which the patient receives highly immunosuppressive conditioning followed by an infusion of a stem cell graft containing unselected populations of mature T cells. In the treatment described here, the graft is engineered to minimize the possibility of sustained donor cell engraftment, and the anti-tumor effector T cells derive from the host. |
申请公布号 |
WO2013169386(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2013US32129 |
申请日期 |
2013.03.15 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
FUCHS, EPHRAIM, JOSEPH;SYMONS, HEATHER, JILL;SWINNEN, LODE |
分类号 |
A61K38/00;A61P7/00;A61P35/00;C12N5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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