发明名称 |
BI-FUNCTIONAL SHORT-HAIRPIN RNA (BI-SHRNA) SPECIFIC FOR SINGLE-NUCLEOTIDE KRAS MUTATIONS |
摘要 |
The present invention includes compositions and methods for making and using a bifunctional shRNAs capable of reducing an expression of a K-ras gene, e.g., a mutated K-ras gene, wherein at least one target site sequence of the bifunctional RNA molecule is located within the K-ras gene and wherein the bifunctional RNA molecule is capable of activating a cleavage-dependent and a cleavage-independent RNA-induced silencing complex for reducing the expression level of K-ras. |
申请公布号 |
CA2872930(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
CA20132872930 |
申请日期 |
2013.05.09 |
申请人 |
GRADALIS, INC. |
发明人 |
RAO, DONALD;WANG, ZHAOHUI;NEMUNAITIS, JOHN J.;SENZER, NEIL |
分类号 |
C12N15/113;A61K9/127;A61K48/00;A61P35/00;B82Y5/00;C12N15/85 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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