发明名称 |
COMBINATION THERAPIES COMPRISING ANTI-ERBB3 AGENTS |
摘要 |
Disclosed are methods and compositions for inhibiting the growth of a tumor (e.g., a malignant tumor) in a subject. In particular, combination therapies for treating a tumor in a subject by co-administering either i) an effective amount of an anti-estrogen agent or ii) an effective amount of a receptor tyrosine kinase inhibitor and an effective amount of a bispecific anti-ErbB2/anti-ErbB3 antibody, and optionally an effective amount of trastuzumab. Also disclosed is a bispecific anti-ErbB2/anti-ErbB3 antibody for use in the therapy of a tumor in combination with either i) an anti-estrogen agent or ii) a receptor tyrosine kinase inhibitor, and optionally in use with trastuzumab. |
申请公布号 |
WO2012116317(A3) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2012US26602 |
申请日期 |
2012.02.24 |
申请人 |
MERRIMACK PHARMACEUTICALS, INC.;ZHANG, BO;MCDONAGH, CHARLOTTE;HUHALOV, ALEXANDRA |
发明人 |
ZHANG, BO;MCDONAGH, CHARLOTTE;HUHALOV, ALEXANDRA |
分类号 |
C07K16/30;A61K39/395;C12P21/08 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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