发明名称 |
SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
摘要 |
<p>Substituted 6-(4-Hydroxy-phenyl)-l H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula, in which R', R2 , R3, R4, R5 and R6 are defined as indicated below. The compounds of the formula I are proteine kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.</p> |
申请公布号 |
WO2013167403(A1) |
申请公布日期 |
2013.11.14 |
申请号 |
WO2013EP58839 |
申请日期 |
2013.04.29 |
申请人 |
SANOFI |
发明人 |
HACHTEL, STEPHANIE;SCHOENAU, CHRISTIAN;LOEHN, MATTHIAS;PLETTENBURG, OLIVER;PFEIFFER-MAREK, STEFANIA;SCHIFFER, ALEXANDER;GAUL, HOLGER;KANNT, AIMO;DEDIO, JUERGEN;DUDDA, ANGELA |
分类号 |
C07D471/04;A61K31/437;A61P3/10;A61P9/00;A61P25/00;A61P29/00;A61P35/00 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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地址 |
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