EUTECTIC COMPOSITION COMPRISING CELECOXIB AND POLOXAMER

摘要

The present invention relates to an eutectic mixture having celecoxib with remarkably enhanced solubility and bioavailability through an eutetic reaction by adding poloxamer of chemical formula 2 to celecoxib of chemical formula 1 which is an insoluble drug. The weight ratio of poloxamer with respect to celecoxib is 3:7-6:4. More preferably, the eutectic mixture according to the present invention contains 1.5 parts by weight of poloxamer with respect to 1 part by weight of celecoxib. [Reference numerals] (AA) Temperature ;(BB) % celecoxib