CEPA DE MICROORGANISMOS TRANSFORMADOS, BEM COMO PROCESSO PARA A PREPARAÇÃO FERMENTATIVA DE L-CISTEÍNA, L-CISTINA, N-ACETIL-SERINA OU DERIVADOS DE TIAZOLIDINA

摘要

A new microbial strain is claimed which is suitable for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine and/or thiazolidine derivatives and over-expresses at least one gene coding for a protein that mediates cellular clearance of antibiotics or other substances that are toxic for the microorganism. Also claimed are: (1) a gene coding for a protein comprising the sequence MSR KDGVLALLVV VVWGLNFVVI KVGLHNMPRL MLAGLRFMLV (SEQ. ID. NO: 1); (2) a gene coding for a protein comprising the sequence: MKFRGGRMSR KDGVLALLVV VVWGLNFVVI KVGLHNMPRL MLAGLRFMLV AFPAIFFVAR PKVPNLLLLG YGLTISFAQF AFLFCAINFG MPAGLASLVL QAQAFFTIML GAFTFGERLH GKQLAGIALA IFGVLVLIED SLNGQHVAML GFMLTLAAAF SWACGNIFNK KIMSHSTRPA VMSLVIWSAL IPIIPFFVAS LILDGSATMI HSLVTIDMTT ILSLMYLAFV ATIVGYGIWG TLLGRYETWR VAPLSLLVPV VGLASAALLL DERLTGLQFL GAVLIMTGLY INVFGLRWRK AVKVGS (SEQ. ID. NO: 2); (3) proteins comprising SEQ. ID. NO: 1; (4) a plasmid containing at least one gene as in (1) or (2).