发明名称 |
A RECEPTOR TREM (TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS) AND USES THEREOF |
摘要 |
Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases are also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-.beta. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
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申请公布号 |
CA2342376(C) |
申请公布日期 |
2013.11.12 |
申请号 |
CA20012342376 |
申请日期 |
2001.03.28 |
申请人 |
COLONNA, MARCO;BOUCHON, AXEL |
发明人 |
COLONNA, MARCO;BOUCHON, AXEL |
分类号 |
C12N15/12;A61K38/17;A61K39/395;A61K48/00;A61P29/00;C07K14/705;C07K16/28;C12N5/08;C12P21/02;C12Q1/68 |
主分类号 |
C12N15/12 |
代理机构 |
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