发明名称 |
Método de identificación de secretagogos de GLP-1 |
摘要 |
The present invention concerns combination of an amount of a GPR1 19 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-I level in a subject over that provided by the amount of the GPR1 19 agonist or the amount of the DPP-FV inhibitor alone and the use of such a combination for treating or preventing diabetes and conditions related thereto or conditions ameliorated by increasing a blood GLP-I level. The present invention also relates to the use of a G protein-coupled receptor to screen for GLP-I secretagogues.
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申请公布号 |
ES2327268(T9) |
申请公布日期 |
2013.11.12 |
申请号 |
ES20060717678T |
申请日期 |
2006.01.09 |
申请人 |
ARENA PHARMACEUTICALS, INC. |
发明人 |
CHU, ZHI-LIANG;LEONARD, JAMES N.;AL-SHAMMA, HUSSIEN A.;JONES, ROBERT M. |
分类号 |
A61K31/00;A61K31/401;A61K31/415;A61K31/4196;A61P3/00;A61P3/10;C12N15/12;G01N33/566;G01N33/58 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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