Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta

摘要

Compounds that inhibit P13Kdelta activity, including compounds that selectively inhibit P13Kdelta activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (P13Kdelta) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which P13Kdelta plays a role in leukocyte function, using the compounds also are disclosed.