发明名称 |
PROCESSO PARA PRODUZIR UMA VACINA COMBINADA, E, VACINA |
摘要 |
The invention provides a process for producing a combined vaccine containing an inactivated Sabin strain of poliovirus, a Bordetella pertussis protective antigen, a diphtheria toxoid and a tetanus toxoid, the process including a step of producing a high-titer Sabin strain poliovirus. The inventive process for producing a combined vaccine, including a step of culturing, in the presence of from about 4 g/L to about 6 g/L of a microcarrier, Vero cells to be inoculated with a Sabin strain of poliovirus, is useful as a process for efficiently producing a combined vaccine containing an inactivated Sabin strain of poliovirus. |
申请公布号 |
BRPI0717145(A2) |
申请公布日期 |
2013.11.12 |
申请号 |
BR2007PI17145 |
申请日期 |
2007.09.28 |
申请人 |
JAPAN POLIOMYELITIS RESEARCH INSTITUTE;TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
SHINOBU ABE;BUNSHICHI SHIMIZU |
分类号 |
A61K39/00;A61K39/05;A61K39/08;A61K39/10;A61K39/13;A61P31/04;A61P31/12 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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