| 摘要 |
The invention relates to a method for preparing morphine-6-glucuronide or one of the derivatives thereof, comprising the following steps: (i) reacting a compound having formula (I), wherein Rrepresents a carbonyl group, CORCO or SORSOwith a glucuronic acid derivative having formula (II) wherein PG represents an acetyl, isobutyryl, benzoyl or pivaloyl group, X represents a trihalogenoacetamidate group and Rrepresents a (C-C)alkylcarboxylate group, in the presence of an aromatic solvent and trifluoromethanesulfonyl of trimethylsilane; (ii) reacting the product obtained in step (i) with a strong basic agent; and, subsequently, (iii) recovering the product obtained in step (ii). |
