| 发明名称 |
BLC-2 SELECTIVE AGENTS CAUSING APOPTOSIS FOR TREATING CANCER AND IMMUNE DISEASES |
| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to compounds of formula Iand formula IVwherein the radical values are such as specified in cl. 1 and 4 of the patent claim, as well as to their therapeutically acceptable salts. Besides, the invention refers to a composition for treating cancer on the basis of the compounds of formula I, to using the compounds of formula I for preparing the therapeutic agent for treating cancer, as well as to using it for treating cancer.EFFECT: there are prepared and described the new compounds which inhibit anti-apoptotic Bcl-2 and Bcl-x protein activity.17 cl, 481 ex |
| 申请公布号 |
RU2497822(C2) |
申请公布日期 |
2013.11.10 |
| 申请号 |
RU20110127402 |
申请日期 |
2009.12.04 |
| 申请人 |
EHBBVI INK. |
发明人 |
BRANKO MILAN;DIN KHUN;DOUEHRTI DZHORDZH A.;EHLMOR STIVEN V.;KHASVOL'D LIZA;KHEKSAMER LAURA;KANZER AARON R.;MANTEJ ROBERT A.;MAKKLELLAN UILL'JAM DZH.;PARK CHANG KH.;PARK CHEHOL-MIN;PETROS EHNDRJU M.;SUN SJAOKHUN;SAUEHRS EHNDRJU DZH.;SALLIVAN DZHERARD M.;TAO CHZHI-FU;VAN GARI T.;VAN LEH;VAN SILU;UEHNDT MAJKL D. |
| 分类号 |
C07D405/12;A61K31/404;A61P35/00;C07D209/32;C07D211/96;C07D213/64;C07D215/20;C07D217/16;C07D235/26;C07D249/04;C07D295/125;C07D295/14;C07D309/14;C07D401/12 |
主分类号 |
C07D405/12 |
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