| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to organic chemistry, namely to new phenylimidazole derivatives of general formula, wherein Rrepresents a hydrogen atom, a phenyl lower-alkyl group or a pyridyl lower-alkyl group with a benzene ring and a pyridine ring are optionally substituted by 1 or 2 substitutes specified in a group consisting of halogen atoms, cyano group and halogen-substituted lower-alkyl groups; one or Rand Rrepresents a hydrogen atom, and another one represents a lower alkoxy group; Rrepresents a lower-alkyl group, a difurylglyoxal group, a thienyl group or a phenyl group optionally substituted by 1 or 2 substitutes specified in a group consisting of lower-alkyl groups, lower-alkoxy groups, halogen atoms, a carboxyl group, lower alkoxycarbonyl groups, and halogen-substituted lower-alkyl groups; Rand Rare identical or different, and represent a hydrogen atom or a lower alkyl group; Rand Rare identical or different, and represent a hydrogen atom or a lower alkoxy group; provided Rrepresents an unsubstituted phenyl lower-alkyl group, Rrepresents a lower alkoxy group, Rrepresents a hydrogen atom, Rrepresents an unsubstituted phenyl group or a phenyl group containing 1 or 2 halogen-substituted lower-alkyl groups, and Rrepresents a hydrogen atom, then Ris other than a hydrogen atom. Also, the invention refers to an LPL activator, an agent for preventing or treating hyperlipidaemia, an agent for treating arteriosclerosis, and an agent for treating obesity on the basis of the compound of formula (1).EFFECT: there are prepared new phenylimidazole derivatives effective for LPL activation.23 cl, 10 tbl, 7 ex |
