| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine, pharmaceutics and nanotechnology, more specifically to a pharmaceutical composition of fluconazole that is an antifungal agent from the group of triazole prepared by chemical synthesis, and a method for preparing it. The presented pharmaceutical composition possessing antifungal activity containing fluconazole coating nanotubes of the various external tube diameter - 60-160 nm, the internal diameter - 10-60 nm and the length - 100-5000 nm in the following relations, wt %: fluconazole - 50-60; alumosilicate nanotubes - 40-50. The method for preparing the pharmaceutical composion consists in the fact that fluconazole is mixed with the alumosilicate nanotubes with the aqueous ethanol environment, and mixing the prepared suspension and evaporating ethanol.EFFECT: using fluconazole applied on the nanotubes enables developing new ointments and gels for treating fungal diseases with the reduced amount of fluconazole.2 cl, 2 dwg, 1 tbl, 3 ex |
