| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: prevent invention refers to organic chemistry, namely to new quinolinone derivatives of general formula(I) or a pharmaceutically acceptable slat, hydrate or solvate thereof, wherein the above compound contains a flexible fragment specified in a group consisting of amide and an ester, directly conjugated with the substitute R, and wherein A represents -O-(CH)-, wherein n represents an integer from 2 to 4; Rrepresents phenyl substituted by one or two substitutes specified in a group consisting of halogen, OH and OCH; R, R, Rand Rindependently represents hydrogen, Calkyl or Calkoxy; Rrepresents hydrogen or Calkyl. Also, the invention refers to the compound of formula(II) and to a method of treating schizophrenia, acute mania, bipolar disorder or depression.EFFECT: there are prepared new compounds showing the effective biological properties.12 cl, 1 tbl, 68 ex |
