| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry, namely to a pharmaceutical composition of levofloxacin. The technical result is ensured by using Klucel and a combination of desintegrants, including sodium starch glycolate and sodium croscarmellose in the composition, with the first desintegrant being introduced before wet granulation, and the second one - after dry granulation together with an antifriction agent that is magnesium stearate.EFFECT: composition possesses a better combination of bioavailability and appearance of tablets, including in storage; as additives, the composition contains microcrystalline cellulose (MCC), sodium starch glycolate, sodium croscarmellose, calcium carbonate, hydroxypropyl cellulose and stearic acids and/or salts thereof.10 cl, 8 ex, 4 tbl |
| 申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE NAUKI INSTITUT ORGANICHESKOGO SINTEZA IM. I.JA. POSTOVSKOGO URAL'SKOGO OTDELENIJA ROSSIJSKOJ AKADEMII NAUK;FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE UCHREZHDENIE "NAUCHNO-ISSLEDOVATEL'SKIJ INSTITUT FARMAKOLOGII IMENI V.V. ZAKUSOVA" ROSSIJSKOJ AKADEMII MEDITSINSKIKH NAUK |
发明人 |
CHARUSHIN VALERIJ NIKOLAEVICH;CHUPAKHIN OLEG NIKOLAEVICH;KOTOVSKAJA SVETLANA KONSTANTINOVNA;BASKAKOVA ZOJA MIKHAJLOVNA;MOCHUL'SKAJA NATALIJA NIKOLAEVNA;NOSOVA EHMILIJA VLADIMIROVNA;SEREDENIN SERGEJ BORISOVICH;PJATIN BORIS MIKHAJLOVICH;ALEKSEEV KONSTANTIN VIKTOROVICH;AVDJUNINA NINA IVANOVNA;GRUSHEVSKAJA LJUBOV' NIKOLAEVNA;BLYNSKAJA EVGENIJA VIKTOROVNA;TIKHONOVA NATAL'JA VIKTOROVNA;GAEVAJA LJUDMILA MIKHAJLOVNA;DUDENKOVA MARIJA EVGEN'EVNA;SERGEEVA MARIJA SERGEEVNA;SEDOVA MARIJA KONSTANTINOVNA |
