| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formulaor a pharmaceutically acceptable salt thereof, wherein Gis phenyl or pyridyl, each of which is optionally additionally substituted by one substitute presented by T; Gis phenyl, 1,3-thiazolyl or 1,3-oxazolyl, wherein Gis bound to Gin the para position in relation to a place of attachment of Gto group NH in formula (I), wherein Gmeans phenyl, Gis bound to Gin the para position of Gin relation to G, and wherein provided Grepresents 1,3-thiazolyl or 1,3-oxazolyl, Gis bound to Gin the position of 5 Gand Gis bound to Gin the position of 2 G; T in each case is independently specified in a group containing Calkyl and halogen; Gis presented by formulaor by formula; Wis -C(R)(R)-C(R)(R)-, and Wrepresents N; or Wrepresents O; Wis -C(R)(R) -; each Rand Ris hydrogen; each Rand Rkis hydrogen; Rand Rtogether with a carbon atom whereto attached, are a 4-5-member cycloalkyl or monocyclic heterocycle of formula; wherein one hydrogen atoms attached to the carbon atom of the cycloalkyl ring and monocyclic heterocycle is optionally substituted by a radical specified in a group -C(O)O(R); Wis -CH- or -CH-CH-; Wis O or N(R), wherein Ris hydrogen, Calkyl or -C(O)O(R); Rin each case is independently Calkyl; Ris hydrogen; Lis O; and X is hydrogen, Calkyl, or - (CRR)-C(O)O(R); or Lis -CH- and X is -C(O)OH; Ris hydrogen; or Q is Gor Y-Y; or Q is described for formulawherein Z is phenyl; Gis benzothiazole or benzoxazole optionally additionally substituted by 1 or 2 substitutes specified in a group consisting of Calkyl, halogen and -OR; Yin each case is independently -C(O)-, -C(O)O- or -C(O)N(R)-, wherein the right side -C(O)O- and -C(O)N(R)- of the groups is attached to Yor (CRR), Yin each case is independently phenyl, benzyl, piperidinyl or bicyclo[4.2.0]octa-1,3,5-triene, wherein the phenyl and benzyl residues are optionally additionally substituted by 1 or 2 substitutes specified in a group consisting of halogen and haloCalkyl; Rand Rin each case is independently hydrogen, or Calkyl; Rin each case is independently halogenCalkyl; Ris hydrogen; and u means 1.EFFECT: compounds being the type 1 diacylglycerol O-acyltransferase (DGAT-1) enzyme inhibitors.7 cl, 1 tbl, 61 ex |
