PHARMACEUTICAL COMPOSITION OF PATTERN-RECOGNISING RECEPTOR LIGANDS, METHODS FOR USING IT AS IMMUNOSTIMULANT FOR TREATING INFECTION CAUSED BY BACTERIAL AND VIRAL PATHOGENS, METHOD FOR USING IT AS ADJUVANT OF VACCINES

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: group of inventions refers to pharmacology and medicine and concerns an immunostimulating composition, and methods for using it for enhancing the immune response, particularly for treating infections caused by bacterial and viral pathogens, to adjuvant compositions and methods for enhancing the antigen immunogenicity when used as an adjuvant of vaccines. The pharmaceutical composition of pattern-recognising receptor ligands contains muramyl peptide of structural formula N-acetylmuramyl-L-alanyl-D-isoglutamine and lipopolysaccharide or lipid A in the following proportions, wt %: muramyl peptide of structural formula N-acetylmuramyl-L-alanyl-D-isoglutamine 0.00001 to 0.01, lipopolysaccharide or lipid A 0.00001 to 0.01, a solvent - the rest.EFFECT: group of inventions provides high immunostimulating activity and prolonged action of the composition.7 cl, 5 ex, 1 tbl, 9 dwg