| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: present invention refers to organic chemistry, namely to new imidazolidin-2,4-dione derivatives of general formulain the form of racemates, enantiomers or any combinations thereof, or to pharmaceutically acceptable salts thereof, wherein Rand Rindependently represent alkyls, halogenalkyls, cyano-, nitro-, amino-, -NR-CO-R, -NR-SO-R, -NR-CO-(CH)-NRR, -NR-SO-(CH)-NRRor -CO-NH; n is specified in 0 and 1; Rrepresents alkyl; Rand Rindependently represent hydrogen atoms, alkyls and alkyloxycarbonyls; Rrepresents a hydrogen atom or alkyl; Rrepresents alkyl, or two radicals Rtogether with a carbon atom whereto attached form cycloalkyl containing 4 members; Rrepresents halogenalkyl containing 4 to 6 carbon atoms; Y represents a linear or branched alkylene containing 5 to 11 carbon atoms; alkylene may be substituted or may contain two additional members -O-; X represents -S-, -SO, -SO-, -S=N(R)- or -S(O)=N(R)-; Rrepresents a hydrogen atom or halogenalkylcarbonyl. Also, the invention refers to the specific compounds of formula (I), to a method for preparing the compound of formula (I) if X = S, to intermediate compounds, to a pharmaceutical composition of the compound of formula (I) and using the compound of formula (I).EFFECT: there are prepared new imidazolidin-2,4-dione derivatives possessing antiproliferative activity.21 cl, 4 dwg, 47 ex |
