| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula, where R and Rindependently denote a link selected from: i) hydrogen; ii) substituted or unsubstituted phenyl and iii) substituted or unsubstituted 5- or 6-member heteroaryl in which heteroatoms are selected from nitrogen, oxygen, sulphur or combinations thereof; said substitutes are selected from: i) C-Clinear, C-Cbranched or C-Ccyclic alkyl; ii) C-Clinear, C-Cbranched or C-Ccyclic alkoxy; iii) C-Clinear, C-Cbranched or C-Ccyclic halogenalkyl; iv) halogen; v) -CN; vi) -NHC(O)Rvii) -C(O)NRR; viii) 5- or 6-member heteroaryl in which heteroatoms are selected from nitrogen, oxygen, sulphur or combinations thereof; or ix) two substitutes may be taken together to form a condensed ring containing 5-7 atoms; Ris C-Clinear, C-Cbranched or C-Ccyclic alkyl; Rand Reach independently denotes: 1) hydrogen; ii) C-Clinear, C-Cbranched or C-Ccyclic alkyl; or iii) Rand Rcan be taken together to form a ring containing 3-7 atoms; Ris selected from: i) -OR; or ii) -NRR; Ris hydrogen or C-Clinear, C-Cbranched or C-Ccyclic alkyl; Rand Reach independently denotes: i) hydrogen; ii) C-Clinear, C-Cbranched or C-Ccyclic alkyl; or iii) Rand Rmay be taken together to form a ring containing 3-7 atoms; Ris hydrogen, methyl or ethyl; L is a binding link of formula -[C(RR)]-Rand Reach independently denotes hydrogen, methyl or ethyl; n ranges from 1 to 3; Ris hydrogen or methyl; or pharmaceutically acceptable salt thereof; provided that R and Rboth denote hydrogen. The invention also relates to compositions based on the described compounds for treating anaemia or assisting wound healing and use of said compounds to prepare a composition for treating anaemia or wounds.EFFECT: novel compounds which are HIF-16 prolyl hydroxylase inhibitors are obtained.14 cl, 18 ex, 15 tbl, 2 dwg |
