New substituted imidazole compounds are Hepatitis C virus RNA replication inhibitor, useful for treating viral infections including West Nile virus, hepatitis B virus, hepatitis C virus, Dengue virus and bovine viral diarrhea virus

摘要

Substituted imidazole compounds (I) are new. Substituted imidazole compounds of formula (I) and their prodrugs, racemic, enantiomers, diastereoisomers, tautomers and salts are new. X : N or CH; A : phenyl, 5C heterocycle including furan, thiophene, pyrrole, imidazole, pyrazole, oxazole or thiazole, 6C heterocycle including pyridine, pyrimidine or pyridazine or fused form of 5C and/or 6C heterocycle; R1 : cyclic pentose in furan form having free or substituted OH groups in the form of ester derivatives, amides, sulfonamides or mono-, bi- or tri- phosphate groups or hexose group in pyran form having free or substituted OH groups in the form of ester derivatives, amides, sulfonamides or mono-, bi- or tri- phosphate groups; and R2-R4 : linear or branched 3-10C-alkyl (substituted by halo, -OH, -NH 2, -CONH 2, -CO 2H, -CO 2-CH 3, -CO 2-C 2H 5, -CN, -C(NH 2)NH, -C(NH-CH 3)NH or -C(NH-C 2H 5)NH), H, halo (preferably Cl, Br, I or F), or -OH, -NH 2, -CONH 2, -CO 2H, -CO 2-CH 3, -CO 2-C 2H 5, -CN, -C(NH 2)NH, -C(NH-CH 3)NH or -C(NH-C 2H 5)NH. [Image] ACTIVITY : Virucide; Antiinflammatory; Hepatotropic. MECHANISM OF ACTION : Hepatitis C virus RNA replication inhibitor. The ability of (I) to inhibit hepatitis C virus RNA replication was tested in FT313 cell line. The result showed that (I) exhibited an IC 5 0 value of less than 5 mu M.