发明名称 |
Antibodies Against Nerve Growth Factor (NGF) With Enhanced In Vivo Stability |
摘要 |
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
|
申请公布号 |
US2013295112(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
US201313886104 |
申请日期 |
2013.05.02 |
申请人 |
ABBOTT RESEARCH B.V.;ABBOTT RESEARCH B.V. |
发明人 |
POWELL JOHN;CASSON DUNCAN;MAGINN MARK;LIU WEI;DUTTA SANDEEP;BEST ANDREA;HALL JERRY A. |
分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|