发明名称 |
ANTIBODIES SELECTIVE FOR CELLS PRESENTING EGFR AT HIGH DENSITY |
摘要 |
Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
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申请公布号 |
US2013295086(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
US201213821832 |
申请日期 |
2012.01.20 |
申请人 |
TIKHOMIROV ILIA ALEXANDRE;JARAMILLO MARIA L.;O'CONNOR-MCCOURT MAUREEN D.;SULEA TRAIAN;GILBERT RENALD;GAILLET BRUNO;BAARDSNES JASON;BANVILLE MYRIAM;GROTHE SUZANNE;NATIONAL RESEARCH COUNCIL OF CANADA;YM BIOSCIENCES INC. |
发明人 |
TIKHOMIROV ILIA ALEXANDRE;JARAMILLO MARIA L.;O'CONNOR-MCCOURT MAUREEN D.;SULEA TRAIAN;GILBERT RENALD;GAILLET BRUNO;BAARDSNES JASON;BANVILLE MYRIAM;GROTHE SUZANNE |
分类号 |
C07K16/30 |
主分类号 |
C07K16/30 |
代理机构 |
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地址 |
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