COMPOSITION AND METHODS FOR PROLONGING SURVIVAL OF PLATELET

摘要

PROBLEM TO BE SOLVED: To provide modified platelets having a reduced platelet clearance and methods for reducing platelet clearance, and to provide a composition for the preservation of platelets.SOLUTION: An apparatus for processing a blood cell sample comprises a sterile first container having one or more ports and containing a preparation of blood cells; and a second sterile container having one or more ports and containing blood cell modifying agents; wherein the first container is adapted to the second container through a sterile conduit reversibly attached to the first container port and the second container port and the conduit further comprises a valve, wherein the blood cell modifying agent is introduced into the first container and the preparation of blood cells therein is rendered cold-storage competent after the blood cells are contacted with the blood modifying agent.