MACHINE FOR PRODUCTION OF SOLID DOSAGE FORMS

摘要

In one aspect, the present invention features a machine for the production of a solid dosage form, the machine including: (a) a die block having one or more forming cavities each having an inner wall, a first opening at the surface of one side of the die block, and a second opening at the surface on the opposite side of the die block; (b) one or more first dosing nozzle adapted to both measure an amount of a first powder blend and discharge the measured amount of the first powder blend within one of the one or more forming cavity; (d) one or more first forming tools each adapted to move into one of the cavities through the first opening of the forming cavity; (e) one or more second forming tools each adapted to move adjacent to one of the second openings or into one of the cavities through the second opening of the forming cavity; (f) at least one first RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; and (g) at least one second RF electrode operably associated with the one or more first forming tools, the one or more second forming tools, or the inner wall of the one or more forming cavities; wherein the machine is adapted to form a dosage form between a first forming tool and a second forming tool within a forming cavity and wherein the first RF electrode and the second RF electrode are arranged within the machine such that when RF energy is applied between the first RF electrode and the second RF electrode, the RF energy passes through the portion of the forming cavity adapted to form the dosage form.