发明名称 |
MOLECULES WITH REDUCED EFFECTOR FUNCTION AND EXTENDED HALF-LIVES, COMPOSITIONS, AND USES THEREOF |
摘要 |
<p>Provided are polypeptides comprising a variant IgG Fc domain, wherein the polypeptides exhibit reduced or ablated effector functions (e.g., ADCC and/or CDC) and increased stability and plasma half-life compared to a parent polypeptide. Also provided are compositions, methods of treatment, and methods to diminish Fc-induced effector function in a parent polypeptide.</p> |
申请公布号 |
WO2013165690(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
WO2013US36872 |
申请日期 |
2013.04.17 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
TSUI, PING;BORROK, MARTIN;DALL'ACQUA, WILLIAM |
分类号 |
A61K39/395;C07K16/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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