发明名称 |
AFFINITY MATURED ANTI-CCR4 HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE |
摘要 |
The present invention provides affinity matured humanized monoclonal antibodies, bi-specific antibodies, antibody conjugates, and fusion proteins that bind to the chemokine receptor CCR4. This antibody is derived from mAb 1567 and recognizes the same epitope. Binding of the antibodies disclosed herein to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells. |
申请公布号 |
WO2013166500(A1) |
申请公布日期 |
2013.11.07 |
申请号 |
WO2013US39744 |
申请日期 |
2013.05.06 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
MARASCO, WAYNE, A.;SUI, JIANHUA;ZHU, QUAN;CHANG, DE-KUAN |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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