发明名称 |
POLYMALIC ACID-BASED NANOBIOPOLYMER COMPOSITIONS AND METHODS FOR TREATING CANCER |
摘要 |
<p>Nanobiopolymeric conjugates based on biodegradable, non-toxic and non- immunogenic poly (ß-L-malic acid) PMLA covalently linked to molecular modules that include morpholino antisense oligonucleotides (AONa), an siRNA or an antibody specific for an oncogenic protein in a cancer cell, and an antibody specific for a transferrin receptor protein, are efficient for treatment a cancer in a subject.</p> |
申请公布号 |
EP2658574(A1) |
申请公布日期 |
2013.11.06 |
申请号 |
EP20100861515 |
申请日期 |
2010.12.30 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
INOUE, SATOSHI;DING, HUI;HOLLER, EGGEHARD;BLACK, KEITH;LJUBIMOVA, JULIA |
分类号 |
A61K47/48;A61K38/16;A61K39/395;A61K47/30;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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