发明名称 |
METHODS AND COMPOSITIONS FOR TREATING HIV |
摘要 |
The invention features nucleic acid constructs encoding chimeric immune T-cell receptors (CIRs) that are useful for treating HIV in patients. In general, the CIRs contain an extracellular domain which targets HIV or HIV infected cells (e.g., the extracellular domain of CD4), a transmembrane domain, and a cytoplasmic domain for mediating T-cell activation (e.g., CD3 zeta and/or the partial extracellular domain of CD28). The invention also features the use of host cells expressing CIRs in the treatment of HIV. |
申请公布号 |
EP2558128(A4) |
申请公布日期 |
2013.11.06 |
申请号 |
EP20110769573 |
申请日期 |
2011.04.14 |
申请人 |
ROGER WILLIAMS MEDICAL CENTER |
发明人 |
JUNGHANS, RICHARD, P.;SELLIAH, NITHIANANDAN |
分类号 |
A61K35/14;A61K48/00;A61P31/18;C07H21/04;C12N5/10 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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