TCR transgenic mouse model for immune disease

摘要

The invention relates to the field of transgenic mammals, methods for investigating T-cell therapeutic function and screening active substances useful in the treatment of immune diseases, preferably autoimmune diseases. The invention relates to a transgenic non-human mammal comprising a transgenic expression construct coding for a MOG-binding T-cell receptor (TCR) ² chain, a T-cell receptor (TCR) protein or nucleic acid that encodes said TCR that is isolated from said transgenic non-human mammal and a method for screening one or more factors for involvement in T-cell therapeutic function in an immune disease.