发明名称 |
VACCINE FOR THE PREVENTION OF BREAST CANCER RELAPSE |
摘要 |
The invention features methods to induce and maintain a protective cytotoxic T-lymphocyte response to a peptide of the HER2/ neu oncogene, E75, with the effect of inducing and maintaining protective or therapeutic immunity against breast cancer in a patient in clinical remission. The methods comprise administering to the patient an effective amount of a vaccine composition comprising a pharmaceutically acceptable carrier, an adjuvant such as recombinant human GM-CSF, and the E75 peptide at an optimized dose and schedule. The methods further comprise administering an annual or semi-annual booster vaccine dose due to declining E75-specific T cell immunity. The invention also features vaccine compositions for use in the methods. |
申请公布号 |
EP2162149(B1) |
申请公布日期 |
2013.11.06 |
申请号 |
EP20080745615 |
申请日期 |
2008.04.11 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. |
发明人 |
PEOPLES, GEORGE E.;SATHIBALAN, PONNIAH |
分类号 |
C07K14/71;A61K38/18;A61K39/00 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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