发明名称 |
Process for preparing voriconazole by using new intermediates |
摘要 |
Provided is a process for preparing Voriconazole represented by Chemical Formula 1. More particularly, the process for preparing Voriconazole of Chemical Formula 1 includes: carrying out the Reformatsky-type coupling reaction between a ketone derivative of Chemical Formula 4 and a pyrimidine derivative of Chemical Formula 5 to obtain a compound of Chemical Formula 3; reacting the substituents halo and oxysulfonyl with a hydrogen donor to obtain racemic Voriconazole of Chemical Formula 2; and carrying out optical isolation of the racemic Voriconazole by adding an adequate optically active acid thereto to obtain Voriconazole having high optical purity with high cost-efficiency and high yield.
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申请公布号 |
US8575344(B2) |
申请公布日期 |
2013.11.05 |
申请号 |
US201113577055 |
申请日期 |
2011.02.01 |
申请人 |
KWON HYUK CHUL;RHO MAN DONG;CHA KYUNG HOI;DONGKOOK PHARMACEUTICAL CO., LTD. |
发明人 |
KWON HYUK CHUL;RHO MAN DONG;CHA KYUNG HOI |
分类号 |
C07D403/06 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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