NUCLEASE-MEDIATED TARGETING WITH LARGE TARGETING VECTORS
摘要
Compositions and methods are provided for making one or more targeted genetic modifications at a target genomic locus by employing homologous recombination facilitated by single or double-strand break at or near the target genomic locus. Compositions and methods for promoting efficiency of homologous recombination between an LTVEC and a target genomic locus in prokaryotic or eukaryotic cells using engineered nucleases are also provided.
申请公布号
WO2013163394(A1)
申请公布日期
2013.10.31
申请号
WO2013US38165
申请日期
2013.04.25
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
FRENDEWEY, DAVID;AUERBACH, WOJTEK;VALENZUELA, DAVID, M.;YANCOPOULOS, GEORGE, D.