ACTIVATABLE ANTIBODIES THAT BIND EPIDERMAL GROWTH FACTOR RECEPTOR AND METHODS OF USE THEREOF
摘要
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti- EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
申请公布号
CA2871458(A1)
申请公布日期
2013.10.31
申请号
CA20132871458
申请日期
2013.04.26
申请人
CYTOMX THERAPEUTICS, INC.
发明人
LOWMAN, HENRY BERNARD;DESNOYERS, LUC ROLAND;LIU, SHOUCHUN;WEST, JAMES WILLIAM;SAGERT, JASON GARY;VASILJEVA, OLGA;MENENDEZ, ELIZABETH-EDNA MARY